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KMID : 0385020010170030225
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Korean Journal of Laboratory Animal Science
2001 Volume.17 No. 3 p.225 ~ p.231
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Fas-mediated apoptosis is not essential for cutaneous wound heeling in mice
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Kim, Kil Soo
Park, Ji Young/Kim, Jong Min/Seong, Je Kyung/Yoon, Yeo Sung/Chang, Dong Woo/Yun, Young Min
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Abstract
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Wound healing is a complex biologic process which may be divided into three phases - inflammation, proliferation, and remodeling. Also it involves a series of rapid increases in specific cell populations that prepare the wound for repair, deposition of new matrix and the maturation of wounds. Inflammation is an essential process in the healing of wounds. Apoptosis plays an distinct roles in the wound healing process the down-regulation of inflammatory cell infiltration and programmed cell death involves down-regulation of fibroblasts and collagen deposition, as required for wound maturation. We are aim to study the effects of fas-mediated apoptosis on the processing of cutaneous wound healing. Wound healing patterns of full-thickness cutaneous wounds was compared between ICR mice and MRL/MpJ-Fas^(lpr)/Fas^(lpr) mice whose fas was spontaneously mutated. Full thickness wound (1.5 × 1.5 ㎝ square) was made on the dorsal skin of mouse. Rates of wound healing were determined by tracing outlines of wound edges onto microscope slides on 1, 2, 3, 4, 5, 6, 7, 9, 11, 13, 15, 18, 21 and 28 days after wounding and then measuring wound areas by use of an image analysis system. Tissues were observed with hematoxylin-eosin staining from paraffin embedded sections. There was not significant differences in the wound healing patterns of full-thickness cutaneous wounds between ICR mice and MRL/lpr mice. Also we could not find any differences in the histopathological findings between ICR mice and MRL/lpr mice. Fas-mediated apoptosis may not be important role for the control and procedures of cutaneous wound healing in mice.
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